Lambert-Eaton Myasthenic Syndrome

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Annotated Information

Classification and Resources

ID 77
ICD-10 ICD10CM:G73.1;
ICD-9-CM ICD9CM:358.1;
MeSH MSH:D015624;


Lambert–Eaton myasthenic syndrome (LEMS, also Lambert–Eaton syndrome, or Eaton–Lambert syndrome) is a rare autoimmune disorder that is characterized by muscle weakness of the limbs It is the result of an autoimmune reaction in which antibodies are formed against presynaptic voltage-gated calcium channels, and likely other nerve terminal proteins, in the neuromuscular junction (the connection between nerves and the muscle that they supply) The prevalence is cases per million Around % of those with LEMS have an underlying malignancy, most commonly small cell lung cancer; it is therefore regarded as a paraneoplastic syndrome (a condition that arises as a result of cancer elsewhere in the body)~Most patients who develop LEMS are usually over years of age, but it may affects someone of any age The diagnosis is usually confirmed with electromyography and blood tests; these also distinguish it from myasthenia gravis (MG), a related autoimmune neuromuscular disease~If the disease is associated with cancer, direct treatment of the cancer often relieves the symptoms of LEMS Other treatments often used are steroids, azathioprine and intravenous immunoglobulin, which suppress the immune system, and pyridostigmine and ,-diaminopyridine, which enhance the neuromuscular transmission Occasionally, plasma exchange is required to remove the antibodies~


Eaton-Lambert syndrome  ; Lambert-Eaton syndrome  ; LEMS  ;


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